Information for Healthcare Professionals

“The demand for predictable treatment modalities in regenerative medicine continues to escalate as researchers seek to gain a better understanding of the cellular and molecular mechanisms involved in regeneration........... We are now entering the era of recombinant protein therapeutics. Long viewed as the technology holding the greatest promise for predictable and successful clinical outcomes, recombinant tissue growth factors provide highly purified, concentrated bio-active proteins with well characterised cell-stimulating activities to enhance regenerative outcomes”¹

¹From Passive to Active: Will recombinant Growth factor Theraputics Revolutionise Regeneration, Wisner-Lynch L, Int J Periodontics Restorative Dentistry 2006; 26 : 409-411 pg409 para1

Clincial Evidence

1. Randomised Clinical trial reported in the Journal of Periodontology

Nevins M, Giannobile WV, McGuire MK, et al. Platelet Derived Growth Factor stimulates bone fill and rate of attachment level gain: Results of a large Multicentre Randomised Controlled Trial. J Periodontology 2005; 76: 2205-2215

2. Guest Editorial

Reynolds M, Aichelmann-Reidy M.E. The Era of Biologics and Reparative Medicine: A Pivotal Clinical Trial of Platelet-Derived Growth factor for Periodontal Regeneration. J. Periodontology 2005; 76:2330-2332

3. 2 year follow up paper McGuire M, Nevins M rhPDGF-BB Promotes healing of Periodontal Defects: 24-Month Clinical and radiographic Observations. Int J Periodontics Restorative Dentisitry 2006; 26: 223-231

4. Recession Defects McGuire M, Sheyer E. Comparison of Recombinant Human Platelet Derived Growth Factor-BB plus a Beta Tricalcium Phosphate and a collagen Membrane to Subepithelial Connective Tissue Grafting for the treatment of Recession Defects: A case series. Int. J Periodontics Restorative Dent 2006; 26: 127-133